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Deletion mapping of the long arm of chromosome 22 in human meningiomas

✍ Scribed by Kenzo Akagi; Hiroki Kurahashi; Norio Arita; Toru Hayakawa; Morito Monden; Takesada Mori; Shinichiro Takai; Isamu Nishisho

Publisher: John Wiley and Sons
Year: 1995
Tongue: French
Weight: 678 KB
Volume: 60
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910600208

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✦ Synopsis

Cytogenetic and molecular genetic analyses have shown that a tumor-suppressor gene for human meningioma is located on the long arm of chromosome 22. Recently, somatic mutations of the NF2 gene have been identified in sporadic meningiomas. However, tumorigenesis of certain cases of meningioma cannot be fully explained by inactivation of the NF2 gene alone. Thus, to obtain some indication as to the existence of another tumorsuppressor gene, it seemed important to re-examine the loss of heterozygosity (LOH) on 22q in sporadic meningioma. A total of 46 sporadic meningiomas was examined for LOH at 20 loci on 22q. LOH was observed in 29 tumors ( 6 3 O ) , of which 13 (28%) showed different patterns of a partial loss of 22q. However, the NF2 locus was retained in one tumor that lost a more distal part of 22q. Moreover, 27 of the 28 tumors which showed LOH at the NR locus also lost alleles at more telomeric loci. These results raise the possibility that another tumor-suppressor gene for meningioma may exist on 22q and that its localization may be distal to the D22S I02 locus.

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