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NF2 gene mutations in meningiomas and vestibular schwannomas

✍ Scribed by Ellen C. Zwarthoff; Albert B. Bianchi; Nicole A. Groen; Nikolai Kley; Bernd R. Seizinger; Anne Hagemeijer; Ellen van Drunen; Dirk Bootsma; Jan W. Koper; Cees J.J. Avezaat; Ronald H. Lekanne Deprez

Book ID
119106320
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
98 KB
Volume
77
Category
Article
ISSN
0165-4608

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## Abstract The __NF2__ gene is a putative tumor‐suppressor gene that, when it is altered in the germline, causes neurofibromatosis type 2, a tumor‐susceptibility disease that mainly predisposes to schwannomas and meningiomas. The recent isolation of the __NF2__ gene on chromosome 22 allows the ide

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Sporadic and inherited schwannomas were scanned for the nature, frequency, and distribution of mutations in the NF2 locus encoding the merlin tumor suppressor protein on 22q. Of 58 tumors, 47% displayed loss of heterozygosity for NFZ, leaving a total of 89 NF2 alleles t o be examined. Pathogenic alt