✦ LIBER ✦

Rates of loss of heterozygosity and mitotic recombination in NF2 schwannomas, sporadic vestibular schwannomas and schwannomatosis schwannomas

✍ Scribed by Hadfield, K D; Smith, M J; Urquhart, J E; Wallace, A J; Bowers, N L; King, A T; Rutherford, S A; Trump, D; Newman, W G; Evans, D G

Book ID: 109972527
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 378 KB
Volume: 29
Category: Article
ISSN: 0950-9232
DOI: 10.1038/onc.2010.363

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Evidence of a four-hit mechanism involvi

Evidence of a four-hit mechanism involving SMARCB1 and NF2 in schwannomatosis-associated schwannomas

✍ Roberta Sestini; Costanza Bacci; Aldesia Provenzano; Maurizio Genuardi; Laura Pa 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

Schwannomatosis is characterized by the onset of multiple intracranial, spinal, or peripheral schwannomas, without involvement of the vestibular nerve, which is instead pathognomonic of neurofibromatosis type 2 (NF2). Recently, a schwannomatosis family with a germline mutation of the SMARCB1 gene on

Frequency and distribution of NF2 mutati

Frequency and distribution of NF2 mutations in schwannomas

✍ Lee B. Jacoby; Mia MacCollin; Rosemary Barone; Vijaya Ramesh; James F. Gusella 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 832 KB

Sporadic and inherited schwannomas were scanned for the nature, frequency, and distribution of mutations in the NF2 locus encoding the merlin tumor suppressor protein on 22q. Of 58 tumors, 47% displayed loss of heterozygosity for NFZ, leaving a total of 89 NF2 alleles t o be examined. Pathogenic alt

Loss of chromosome 22 alleles in human s

Loss of chromosome 22 alleles in human sporadic spinal schwannomas

✍ Bertrand Fontaine; Mark P. Hanson; Jean Paul Von Sattel; Robert L. Martuza; Dr J 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 453 KB

Acoustic neuromas occur either as sporadic solitary tumors in the general population or as inherited bilateral tumors typically in patients with neurofibromatosis type 2. Loss of heterozygosity for markers on the long arm of chromosome 22 has been reported in both instances, and neurofibromatosis ty

Predominant occurrence of somatic mutati

Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas

✍ P. Mérel; K. Hoang-Xuan; M. Sanson; A. Moreau-Aubry; E. K. Bijlsma; C. Lazaro; J 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 469 KB 👁 2 views

## Abstract The __NF2__ gene is a putative tumor‐suppressor gene that, when it is altered in the germline, causes neurofibromatosis type 2, a tumor‐susceptibility disease that mainly predisposes to schwannomas and meningiomas. The recent isolation of the __NF2__ gene on chromosome 22 allows the ide

Radiosurgical treatment of vestibular sc

Radiosurgical treatment of vestibular schwannomas in patients with neurofibromatosis type 2 : Tumor control and hearing preservation

✍ Ji Hoon Phi; Dong Gyu Kim; Hyun-Tai Chung; Joongyub Lee; Sun Ha Paek; Hee-Won Ju 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 302 KB 👁 1 views

Angiogenesis in vestibular schwannomas:

Angiogenesis in vestibular schwannomas: Expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1

✍ Martin Nue Møller; Kim Werther; Amarnadh Nalla; Sven-Eric Stangerup; Jens Thomse 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 618 KB

## Abstract ## Objectives/Hypothesis: Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis. It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expres