✦ LIBER ✦

New technologies for high-throughput screening

✍ Scribed by Jonathan J Burbaum; Nolan H Sigal

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 743 KB
Volume: 1
Category: Article
ISSN: 1367-5931
DOI: 10.1016/s1367-5931(97)80111-1

No coin nor oath required. For personal study only.

✦ Synopsis

To screen efficiently the millions of compounds that are synthesized using combinatorial and automated methods, dramatically improved assay technologies are currently needed. In 96-well microtiter plates, nonradioactive techniques (primarily fluorimetric) and cell-based functional methods have moved to the cutting edge, while clever assays that extract information from large bead-based combinatorial libraries have begun to show considerable promise. In the future, miniaturized assays that break out of the 96-well format will be enabled by innovative technologies for high-throughput screening.

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