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New Synthesis of 5-Carboxy-2′-deoxyuridine and Its Incorporation into Synthetic Oligonucleotides

✍ Scribed by Guerniou, V.; Gasparutto, D.; Sauvaigo, S.; Favier, A.; Cadet, J.

Book ID: 120625716
Publisher: Taylor and Francis Group
Year: 2003
Tongue: English
Weight: 180 KB
Volume: 22
Category: Article
ISSN: 0732-8311
DOI: 10.1081/NCN-120022739

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## Abstract A reinvestigation into the synthesis of oligonucleotides containing 5‐(β‐D‐glucopyranosyloxymethyl)‐2′‐deoxyuridine revealed that existing procedures for the preparation of these DNA fragments suffered from decomposition at the final deprotection step. The decomposition product was iden