5-Heteroaryl-2'-deoxyuridine Analogs. Synthesis and Incorporation into High-Affinity Oligonucleotides
✍ Scribed by Gutierrez, Arnold J.; Terhorst, Terry J.; Matteucci, Mark D.; Froehler, Brian C.
- Book ID
- 126184651
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 521 KB
- Volume
- 116
- Category
- Article
- ISSN
- 0002-7863
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## Abstract A reinvestigation into the synthesis of oligonucleotides containing 5‐(β‐D‐glucopyranosyloxymethyl)‐2′‐deoxyuridine revealed that existing procedures for the preparation of these DNA fragments suffered from decomposition at the final deprotection step. The decomposition product was iden
A O l c 5-h b s u p h c p i m n s o w c e m s c a e d c w W d 0 1 E S L 5-Hydroxy-2'-deoxycytidirte (5-OHdC) 2 is one of the major stable "OH radicals and one-electron mediated oxidation products of 2'-deoxycytidine 1. Diflkrent studies have ahovm that the level of 2 increases substantially when DN