𝔖 Bobbio Scriptorium
✦   LIBER   ✦

New strategy for the synthesis of key anthracycline precursors

✍ Scribed by John F. Honek; Michael L. Mancini; Bernard Belleau

Book ID
108381808
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
213 KB
Volume
24
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Synthesis of the Key Precursor of Hirsut
Synthesis of the Key Precursor of Hirsutellide A
✍ Xu, Yanjie; Duan, Xuemin; Li, Meiling; Jiang, Liqin; Zhao, Guangle; Meng, Yi; Ch πŸ“‚ Article πŸ“… 2005 πŸ› Molecular Diversity Preservation International 🌐 English βš– 183 KB
An asymmetric synthesis of the key precu
An asymmetric synthesis of the key precursor to (βˆ’)-indolizomycin
✍ Michael D. Groaning; A.I. Meyers πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 265 KB

Using chiral bicyclic lactams, containing an oc,fi-unsaturation, the key precursor of (-)-indolizomycin was obtained in optically pure form. The sequence involved a >20:1 diastereoselective cyclopropanation of the unsaturated lactam 5 employing sulfoxonium methylide. Tic14 mediated addition of allyl

New strategy for racemization of 2-amino
New strategy for racemization of 2-amino-1,3-propanediols, key intermediates for the synthesis of antibiotic drugs
✍ Claudio Giordano; Silvia Cavicchioli; Silvio Levi; Marco Villa πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 211 KB

A new strategy for racemization of the 2-amino-l ,3-propanediol 2&, based on a chemoselective oxazoline ring formation and a highly diastereoselective reduction of the ketone 2 is reported. Thiamphenicol 1,' threo-(1R,2R)-2-dichloroacetamido-l-(4-me~hylsulfonyl)-l ,3-propanediol, possesses a fairly