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New strategy for racemization of 2-amino-1,3-propanediols, key intermediates for the synthesis of antibiotic drugs

✍ Scribed by Claudio Giordano; Silvia Cavicchioli; Silvio Levi; Marco Villa

Book ID: 104216831
Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 211 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80813-8

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✦ Synopsis

A new strategy for racemization of the 2-amino-l ,3-propanediol 2&, based on a chemoselective oxazoline ring formation and a highly diastereoselective reduction of the ketone 2 is reported. Thiamphenicol 1,' threo-(1R,2R)-2-dichloroacetamido-l-(4-me~hylsulfonyl)-l ,3-propanediol, possesses a fairly wide spectrum of antimicrobial activity against gram-negative bacteria, while

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