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Control of the diels-alder addition regioselectivity by remote substituents. Synthesis of anthracycline precursors.

✍ Scribed by Joaquin Tamariz; Luis Schwager; John H.A. Stibbard; Pierre Vogel


Book ID
104217141
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
285 KB
Volume
24
Category
Article
ISSN
0040-4039

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T7ze regioseZectivity of the EtAlCZ -cataZyzed addition of methyl vinyl ketone to the titZe diene can be reversed by solvent modz &cation. 9 The chemical properties of the diene moieties in 2,3-bis(methylene)bicycloC2.2.l]alkanes can be affected by remote substitution at C(5) and C(6).' For example