New selective amplifier genes containing c-Mpl for hematopoietic cell expansion
β Scribed by Takeyuki Nagashima; Yasuji Ueda; Yutaka Hanazono; Akihiro Kume; Hiroaki Shibata; Naohide Ageyama; Keiji Terao; Keiya Ozawa; Mamoru Hasegawa
- Book ID
- 117053539
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 361 KB
- Volume
- 303
- Category
- Article
- ISSN
- 0006-291X
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## Abstract ## Background Hematopoietic stemβcellβdirected gene transfer has achieved limited success in transducing clinically relevant levels of target cells. The expansion of geneβmodified cells is one way to circumvent the problem of inefficient transduction with current vectors. To this end,
## Abstract ## Background __In vivo__ expansion of geneβmodified cells would be a promising approach in the field of hematopoietic stem cell gene therapy. To this end, we previously developed a selective amplifier gene (SAG), a chimeric gene encoding the granulocyte colonyβstimulating factor (GβCS