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Development of a modified selective amplifier gene for hematopoietic stem cell gene therapy

✍ Scribed by Matsuda, K M; Kume, A; Ueda, Y; Urabe, M; Hasegawa, M; Ozawa, K

Book ID: 110038418
Publisher: Nature Publishing Group
Year: 1999
Tongue: English
Weight: 556 KB
Volume: 6
Category: Article
ISSN: 0969-7128
DOI: 10.1038/sj.gt.3300906

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## Abstract ## Background Hematopoietic stem‐cell‐directed gene transfer has achieved limited success in transducing clinically relevant levels of target cells. The expansion of gene‐modified cells is one way to circumvent the problem of inefficient transduction with current vectors. To this end,