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New resolution approach for large-scale preparation of enantiopure didesmethylsibutramine (DDMS)

✍ Scribed by Zhengxu Han; Dhileepkumar Krishnamurthy; Q.Kevin Fang; Stephen A. Wald; Chris H. Senanayake

Book ID
108283665
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
186 KB
Volume
14
Category
Article
ISSN
0957-4166

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D-Alloisoleucine (D-aIle) was obtained by the resolution of the epimer mixture of L-isoleucine (L-Ile) and D-aIle, which was formed by epimerization of L-Ile, with a resolving agent such as (2S,3S)-dibenzoyltartaric acid ((2S,3S)-DBTA) or (2S,3S)-di-4-toluoyl tartaric acid ((2S,3S)-DTTA).