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New Pyrimido[5,4- b ]indoles as Ligands for α 1 -Adrenoceptor Subtypes

✍ Scribed by Romeo, Giuseppe; Materia, Luisa; Manetti, Fabrizio; Cagnotto, Alfredo; Mennini, Tiziana; Nicoletti, Ferdinando; Botta, Maurizio; Russo, Filippo; Minneman, Kenneth P.

Book ID
126851868
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
418 KB
Volume
46
Category
Article
ISSN
0022-2623

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## Abstract A new series of 3‐[ω‐[4‐(4‐substituted phenyl)piperazin‐1‐yl]alkyl]‐5__H__‐pyrimido[5,4‐__b__]indole‐(1__H__,3__H__)‐2,4‐diones (**3–10** and **12–13**) were synthesized from the __N__‐(2‐chloroethyl)‐__N'__‐[3‐(2‐ethoxycarbonyl)indolyl] urea (**1**) or the __N__‐(3‐chloropropyl)‐__N'__