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New preparation of [123I]PE2I: investigation of the oxidation and purification steps

✍ Scribed by E. Berthommier; C. Loc'h; S. Chalon; C. Olivier; P. Emond; H. Dao Boulanger; M.A. Lelait; L. Mauclaire

Publisher
John Wiley and Sons
Year
2002
Tongue
French
Weight
105 KB
Volume
45
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

In order to simplify preparation of [^123^I]PE2I, iodogen and hydrogen peroxide were examined as oxidants for the preparation of radioiodinated PE2I, e.g. (E)‐N‐(3‐iodoprop‐2‐enyl)‐2__β__‐carbomethoxy‐3__β__‐(4′‐tolyl) nortropane). Among the oxidizing compounds assayed, iodogen appears to afford the best results for this purpose (high radiochemical yield, high chemical purity and a reasonable reaction time). A simplified and efficient method is described here for the preparation of [^123^I]PE2I based on the exchange of a ^123^I tributyl tin analogue in oxidative conditions followed by purification by solid phase extraction (SPE). Using this method, [^123^I]PE2I was obtained with a radio‐pharmaceutical yield over 60%, with chemical and radiochemical purities higher than 95% without the addition of a carrier (Na^127^I) (2G Bq/nmol) or with a specific activity adjusted to 85–90 MBq/nmol in the presence of the carrier. Copyright © 2002 John Wiley & Sons, Ltd.

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