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New Neplanocin Analogues. 7. Synthesis and Antiviral Activity of 2-Halo Derivatives of Neplanocin A 1

โœ Scribed by Obara, Takumi; Shuto, Satoshi; Saito, Yasuyoshi; Snoeck, Robert; Andrei, Graciela; Balzarini, Jan; De Clercq, Erik; Matsuda, Akira

Book ID
119978932
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
220 KB
Volume
39
Category
Article
ISSN
0022-2623

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๐Ÿ“œ SIMILAR VOLUMES

New neplanocin analogues. 10. The conver
New neplanocin analogues. 10. The conversion of adenosine to neplanocin A, a carbocyclic nucleoside antibiotic with potent antiviral activity
โœ Satoshi Niizuma; Satoshi Shuto; Akira Matsuda ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 735 KB

Synthesis of neplanocin A, a potent antiviral carbocyclic nucleoside, from adenosine was achieved. An acyclic adeninenucleoside 21, prepared from adenosine, was converted to 4'-keto acyclic derivative 27. When 27 was treated with lithiotrimethylsilyldiazomethane in THF, a C-H insertion reaction at t