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New hypoxia-selective cytotoxines derived from quinoxaline 1,4-dioxides

✍ Scribed by A. Monge; J. A. Palop; Mercedes González; F. J. Martínez-Crespo; Adela López De Ceráin; Yolanda Sáinz; Susana Narro; A. J. Barker; E. Hamilton

Book ID
112131313
Publisher
Journal of Heterocyclic Chemistry
Year
1995
Tongue
English
Weight
388 KB
Volume
32
Category
Article
ISSN
0022-152X

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## Abstract A problem that confronts clinicians in the treatment of cancer is the resistance of hypoxic tumors to chemotherapy and radiation therapy. Thus, the development of new drugs that are toxic to hypoxic cells found in solid tumors is an important objective for effective anticancer chemother