✦ LIBER ✦

DNA-Targeted 1,2,4-Benzotriazine 1,4-Dioxides: Potent Analogues of the Hypoxia-Selective Cytotoxin Tirapazamine

✍ Scribed by Hay, Michael P.; Pruijn, Frederik B.; Gamage, Swarna A.; Liyanage, H. D. Sarath; Kovacs, Mary S.; Patterson, Adam V.; Wilson, William R.; Brown, J. Martin; Denny, William A.

Book ID: 127098835
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 206 KB
Volume: 47
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm030399c

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Structure−Activity Relationships of 1,2,

Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

✍ Hay, Michael P.; Gamage, Swarna A.; Kovacs, Mary S.; Pruijn, Frederik B.; Anders 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 195 KB

Characterization of Radicals Formed Foll

Characterization of Radicals Formed Following Enzymatic Reduction of 3-Substituted Analogues of the Hypoxia-Selective Cytotoxin 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine)

✍ Shinde, Sujata S.; Maroz, Andrej; Hay, Michael P.; Patterson, Adam V.; Denny, Wi 📂 Article 📅 2010 🏛 American Chemical Society 🌐 English ⚖ 818 KB

492 Novel hypoxia-selective 1,2,4-benzot

492 Novel hypoxia-selective 1,2,4-benzotriazine 1,4-dioxides with improved extravascular transport: analogues of Tirapazamine with in vivo activity

✍ M.P. Hay; R.F. Anderson; W.A. Denny; K.O. Hicks; F.B. Pruijn; B.G. Siim; W.R. Wi 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 140 KB

Toward Hypoxia-Selective DNA-Alkylating

Toward Hypoxia-Selective DNA-Alkylating Agents Built by Grafting Nitrogen Mustards onto the Bioreductively Activated, Hypoxia-Selective DNA-Oxidizing Agent 3-Amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine)

✍ Johnson, Kevin M.; Parsons, Zachary D.; Barnes, Charles L.; Gates, Kent S. 📂 Article 📅 2014 🏛 American Chemical Society 🌐 English ⚖ 609 KB

DNA Base Damage by the Antitumor Agent 3

DNA Base Damage by the Antitumor Agent 3-Amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine)

✍ Birincioglu, Mustafa; Jaruga, Pawel; Chowdhury, Goutam; Rodriguez, Henry; Dizdar 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 130 KB

Oxidative DNA base damage by the antitum

Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-Dioxide (Tirapazamine)

✍ Delshanee Kotandeniya; Brian Ganley; Kent S. Gates 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 160 KB