✦ LIBER ✦

Tricyclic [1,2,4]Triazine 1,4-Dioxides As Hypoxia Selective Cytotoxins

✍ Scribed by Hay, Michael P.; Hicks, Kevin O.; Pchalek, Karin; Lee, Ho H.; Blaser, Adrian; Pruijn, Frederik B.; Anderson, Robert F.; Shinde, Sujata S.; Wilson, William R.; Denny, William A.

Book ID: 111656162
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 465 KB
Volume: 51
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm800967h

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

New hypoxia-selective cytotoxines derive

New hypoxia-selective cytotoxines derived from quinoxaline 1,4-dioxides

✍ A. Monge; J. A. Palop; Mercedes González; F. J. Martínez-Crespo; Adela López De 📂 Article 📅 1995 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 388 KB

258 POSTER Tricyclic triazin 1,4-dioxide

258 POSTER Tricyclic triazin 1,4-dioxides: a new class of hypoxia-selective cytotoxins with improved extravascular transport compared to tirapazamine

✍ M.P. Hay; K.O. Hicks; B.G. Siim; F.B. Pruijn; H.H. Lee; S. Yang; K. Pchalek; A. 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 137 KB

DNA-Targeted 1,2,4-Benzotriazine 1,4-Dio

DNA-Targeted 1,2,4-Benzotriazine 1,4-Dioxides: Potent Analogues of the Hypoxia-Selective Cytotoxin Tirapazamine

✍ Hay, Michael P.; Pruijn, Frederik B.; Gamage, Swarna A.; Liyanage, H. D. Sarath; 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 206 KB

ChemInform Abstract: New Hypoxia-Selecti

ChemInform Abstract: New Hypoxia-Selective Cytotoxines Derived from Quinoxaline 1,4- Dioxides.

✍ A. MONGE; J. A. PALOP; M. GONZALEZ; F. J. MARTINEZ-CRESPO; A. LOPEZ DE CERAIN; Y 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB

Quinoxaline 1,4-dioxides: Hypoxia-select

Quinoxaline 1,4-dioxides: Hypoxia-selective therapeutic agents

✍ Mona Diab-Assef; Makhluf J. Haddadin; Pierre Yared; Chafika Assaad; Hala U. Gali 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB

## Abstract A problem that confronts clinicians in the treatment of cancer is the resistance of hypoxic tumors to chemotherapy and radiation therapy. Thus, the development of new drugs that are toxic to hypoxic cells found in solid tumors is an important objective for effective anticancer chemother

Structure−Activity Relationships of 1,2,

Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

✍ Hay, Michael P.; Gamage, Swarna A.; Kovacs, Mary S.; Pruijn, Frederik B.; Anders 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 195 KB