New compartment- and model-independent method for rapid calculation of drug absorption rates
โ Scribed by Win L. Chiou
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 761 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Data are mean predicted k values. Conditions: (A) nine data sets, 10% random error; (6) six data sets, 20% random error; (C) nine data sets, limited Cand t,10% random error. The real value of k for conditions A-C is 0.5. Values in parentheses are coefficients of variation; ranges are ranges of predi
It has been shown previously that it is impossible to measure the volume of distribution at steady state conclusively for a multicompartment system from an iv bolus dose only. The problem lies in deciding from which compartment elimination of the drug occurs in the compartmental model. In this paper
t in pharmacokinetics the Wagner-Nelson method is oftcn ,.:':,,~ti for cstiwating the absorption rate of a drug in different situations. The program described here a~plic, ibis method to a cnc-o,mpartment model for pla,,,ma drug concentrations an,; comes with several graphs, statistical tests and el
A method has been derived for calculating the mean absorption time of an oral drug and its interconversion metabolite which is generated from the drug systemically and presystemically. The method evolves from the convolution integral and requires plasma AUC and AUMC values after separate intravenous