The objective of this work was to develop a simple residual method to estimate the rate constant for actual or apparent zero-order absorption into a one-compartment model. The method is based on the fact that, in theory, a plot of residuals versus e 7Kt is linear for a zero-order absorption process,
A minicomputer program for estimation of first-order absorption rate in a one-compartment model by the Wagner-Nelson method
โ Scribed by Maurizio Rocchetti; Renato Urso
- Publisher
- Elsevier Science
- Year
- 1982
- Weight
- 274 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0010-468X
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โฆ Synopsis
t in pharmacokinetics the Wagner-Nelson method is oftcn ,.:':,,~ti for cstiwating the absorption rate of a drug in different situations. The program described here a~plic, ibis method to a cnc-o,mpartment model for pla,,,ma drug concentrations an,; comes with several graphs, statistical tests and elaborations for correct, complete use of the method.
๐ SIMILAR VOLUMES
Data are mean predicted k values. Conditions: (A) nine data sets, 10% random error; (6) six data sets, 20% random error; (C) nine data sets, limited Cand t,10% random error. The real value of k for conditions A-C is 0.5. Values in parentheses are coefficients of variation; ranges are ranges of predi