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Evaluation of methods for estimating the rate constant of a one-compartment absorption model when absorption and elimination rate constants are equal

✍ Scribed by John F. Hoke; William R. Ravis

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 223 KB
Volume: 81
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600810424

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✦ Synopsis

Data are mean predicted k values. Conditions: (A) nine data sets, 10% random error; (6) six data sets, 20% random error; (C) nine data sets, limited Cand t,10% random error. The real value of k for conditions A-C is 0.5. Values in parentheses are coefficients of variation; ranges are ranges of prediction. Values are concentrations in plasma at 0.5, 1, 2, 4, 6, and 8 h.

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