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Oral and IV dosing: A method to determine the compartment of drug elimination for two-compartment models

✍ Scribed by J.W.T. Yates; P.A. Arundel

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 91 KB
Volume: 97
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.21166

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✦ Synopsis

It has been shown previously that it is impossible to measure the volume of distribution at steady state conclusively for a multicompartment system from an iv bolus dose only. The problem lies in deciding from which compartment elimination of the drug occurs in the compartmental model. In this paper a new modelling strategy is examined whereby the compartment of elimination may be identified uniquely for the case of two-compartment models. The two models examined predict different profiles in the absorption phase of an oral profile. An in vivo data set is provided that favours a peripheral elimination explanation of its observed pharmacokinetics, based on the 'goodness of fit'.

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