Prutecting groups which permit modification of solubility properties of peptide derivatives or which can act as "handles",1 allowing isolation by selective affinity, offer great potential for facilitating the manipulations of peptide chemistry."2 We report preparation and properties of p-dihydroxybo
New C-protective group for peptide synthesis
โ Scribed by MUTULIS, F. ;MUTULE, I. ;BALODIS, J. ;SEKACIS, I. ;BRIVKALNE, L. ;IPENS, G.
- Book ID
- 115099450
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 598 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0367-8377
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๐ SIMILAR VOLUMES
Acetol can be conveniently used as a reagent for the protection of carboxylic acids in peptide synthesis. It has been found to be inert and stable to hydrogenolytic and acidolytic conditions normally used in peptide synthesis. Deblocking has been selectively achieved under mild conditions using Bu4N
## Abstract The preparation and properties of thirty two N(ฮฑ)โ[2โ(__p__โphenylazophenyl)โisopropylcarbonyl]โaminoโacids and derivatives are described. The new coloured protecting group (AZOCโ) can be easily and selectively removed with mild acid treatment, much the same as the 2โ(biphenyl)โisopropy