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(p-Phenylazophenyl)-Isopropyloxycarbonyl, a New Protecting Group for Peptide Synthesis

✍ Scribed by Aung Tun-Kyi; Robert Schwyzer

Publisher
John Wiley and Sons
Year
1976
Tongue
German
Weight
267 KB
Volume
59
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The preparation and properties of thirty two N(α)‐[2‐(p‐phenylazophenyl)‐isopropylcarbonyl]‐amino‐acids and derivatives are described. The new coloured protecting group (AZOC‐) can be easily and selectively removed with mild acid treatment, much the same as the 2‐(biphenyl)‐isopropyloxycarbonyl (BPOC‐)group. It is introduced via quite stable and yet reactive, crystalline intermediates, AZOC‐OPh and AZOC‐N~3~.

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