New approaches for the detection of minimal residual disease in acute myeloid leukemia
β Scribed by Anna van Rhenen; Bijan Moshaver; Gert J. Ossenkoppele; Gerrit Jan Schuurhuis
- Book ID
- 107540171
- Publisher
- Current Science Inc.
- Year
- 2007
- Tongue
- English
- Weight
- 855 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1558-8211
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## Abstract Two highly sensitive methods, multiparameter flow cytometry (MFC) and realβtime quantitative PCR (RQβPCR), are increasingly used to monitor minimal residual disease (MRD) and to guide riskβadapted management in acute myeloid leukemia (AML). An independent prognostic impact has been demo
Patients with acute leukemia in clinical remission may still have up to 10 10 residual malignant cells (the upper limit of detection by standard morphologic techniques). Sensitive techniques to detect minimal residual disease (MRD) may allow better estimates of the leukemia burden and help the selec