Progress of Minimal Residual Disease Studies in Childhood Acute Leukemia
β Scribed by Dario Campana
- Book ID
- 107540279
- Publisher
- Current Science Inc.
- Year
- 2010
- Tongue
- English
- Weight
- 161 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1558-8211
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Two highly sensitive methods, multiparameter flow cytometry (MFC) and realβtime quantitative PCR (RQβPCR), are increasingly used to monitor minimal residual disease (MRD) and to guide riskβadapted management in acute myeloid leukemia (AML). An independent prognostic impact has been demo
## Abstract In vivo response to initial therapy, as assessed by determination of minimal residual disease (MRD) after 5 and 12 weeks of treatment, has evolved as a strong prognostic factor in children with acute lymphoblastic leukemia (ALL) treated according to the BFM regime. Individual treatment
Patients with acute leukemia in clinical remission may still have up to 10 10 residual malignant cells (the upper limit of detection by standard morphologic techniques). Sensitive techniques to detect minimal residual disease (MRD) may allow better estimates of the leukemia burden and help the selec