✦ LIBER ✦

New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamates

✍ Scribed by Temple, Carroll; Rener, Gregory A.; Comber, Robert N.

Book ID: 127029813
Publisher: American Chemical Society
Year: 1989
Tongue: English
Weight: 701 KB
Volume: 32
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00130a023

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Antimitotic agents. Alterations at the 2

Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates

✍ Temple, Carroll; Rener, Gregory A.; Comber, Robert N.; Waud, William R. 📂 Article 📅 1991 🏛 American Chemical Society 🌐 English ⚖ 855 KB

Chirality and Spectroscopic Changes Indu

Chirality and Spectroscopic Changes Induced by the Recognition of Ethyl 5-Amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl Carbamate Analogs by Tubulin

✍ V. Peyrot; P. Barbier; M. Sarrazin; C. Briand; J. M. Andreu 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 877 KB

Theoretical studies of the ground state

Theoretical studies of the ground state and of the spectroscopic properties of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate analogs

✍ M. Sarrazin; P. Barbier; C. Briand; V. Peyrot 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 192 KB

The Active GTP- and Ground GDP-Liganded

The Active GTP- and Ground GDP-Liganded States of Tubulin Are Distinguished by the Binding of Chiral Isomers of Ethyl 5-Amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4- b ]pyrazin-7-yl Carbamate †

✍ Barbier, Pascale; Peyrot, Vincent; Leynadier, Daniel; Andreu, José Manuel 📂 Article 📅 1998 🏛 American Chemical Society 🌐 English ⚖ 205 KB

Synthesis of [14C]CI-980, ethyl [5-amino

Synthesis of [14C]CI-980, ethyl [5-amino-1,2-dihydro-2(S)-methyl-3-[14C]phenylpyrido[3,4- 6]pyrazin-7-YL]carbamate isethionate salt, a tubulin-binding, antimitotic, broad-spectrum antitumor agent

✍ Peter W. K. Woo; Helen T. Lee 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 408 KB

## Abstract [^14^C]CI‐980 (14b) was synthesized in eight steps starting from [U‐^14^C]benzene (5), which was converted to bromo[^14^C]benzene (6) in the presence of tetrabutylammonium bromide as catalyst. Reaction of 6 with the anion of __N__‐ethoxycarbonyl‐__N__′‐methoxy‐__N__′‐methyl‐L‐alaninamid

Synthesis of [3H]CI-980, ethyl[5-anino-1

Synthesis of [3H]CI-980, ethyl[5-anino-1,2-dihydro-2(S)-methyl-3(3-[3H]phenyl)pyrido[3,4-b]jpyrazin-7-YL] carbamate isethionate salt, a tubulin-binding, antimitotic, broad-spectrum antitumor agent

✍ Helen T. Lee; Peter W. K. Woo 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 226 KB

## Abstract [^3^H]CI‐980 (10b) was synthesized in an eight‐step sequence with an overall yield of 2.4%. Reaction of __m__‐bromophenyl lithium (2) with __N__‐ethoxycarbonyl‐L‐alanine gave the chiral ketone 3. Reduction of 3 with sodium borohydride followed by alkaline __N__‐deprotection and condensa