Antimitotic agents. Alterations at the 2,3-positions of ethyl (5-amino-1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates
✍ Scribed by Temple, Carroll; Rener, Gregory A.; Comber, Robert N.; Waud, William R.
- Book ID
- 121506292
- Publisher
- American Chemical Society
- Year
- 1991
- Tongue
- English
- Weight
- 855 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0022-2623
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## Abstract [^3^H]CI‐980 (10b) was synthesized in an eight‐step sequence with an overall yield of 2.4%. Reaction of __m__‐bromophenyl lithium (2) with __N__‐ethoxycarbonyl‐L‐alanine gave the chiral ketone 3. Reduction of 3 with sodium borohydride followed by alkaline __N__‐deprotection and condensa