✦ LIBER ✦

The Active GTP- and Ground GDP-Liganded States of Tubulin Are Distinguished by the Binding of Chiral Isomers of Ethyl 5-Amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4- b ]pyrazin-7-yl Carbamate †

✍ Scribed by Barbier, Pascale; Peyrot, Vincent; Leynadier, Daniel; Andreu, José Manuel

Book ID: 126951683
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 205 KB
Volume: 37
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi970568t

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Chirality and Spectroscopic Changes Indu

Chirality and Spectroscopic Changes Induced by the Recognition of Ethyl 5-Amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl Carbamate Analogs by Tubulin

✍ V. Peyrot; P. Barbier; M. Sarrazin; C. Briand; J. M. Andreu 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 877 KB

Theoretical studies of the ground state

Theoretical studies of the ground state and of the spectroscopic properties of ethyl 5-amino-2-methyl-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl carbamate analogs

✍ M. Sarrazin; P. Barbier; C. Briand; V. Peyrot 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 192 KB

New anticancer agents: alterations of th

New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamates

✍ Temple, Carroll; Rener, Gregory A.; Comber, Robert N. 📂 Article 📅 1989 🏛 American Chemical Society 🌐 English ⚖ 701 KB

Synthesis of [14C]CI-980, ethyl [5-amino

Synthesis of [14C]CI-980, ethyl [5-amino-1,2-dihydro-2(S)-methyl-3-[14C]phenylpyrido[3,4- 6]pyrazin-7-YL]carbamate isethionate salt, a tubulin-binding, antimitotic, broad-spectrum antitumor agent

✍ Peter W. K. Woo; Helen T. Lee 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 408 KB

## Abstract [^14^C]CI‐980 (14b) was synthesized in eight steps starting from [U‐^14^C]benzene (5), which was converted to bromo[^14^C]benzene (6) in the presence of tetrabutylammonium bromide as catalyst. Reaction of 6 with the anion of __N__‐ethoxycarbonyl‐__N__′‐methoxy‐__N__′‐methyl‐L‐alaninamid