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New 2H-Tetrahydro-1,3,5-thiadiazine-2-thiones Incorporating Glycine and Glycinamide as Potential Antifungal Agents.

✍ Scribed by Tarek Aboul-Fadl; Mostafa A. Hussein; Abdel-Nasser El-Shorbagi; Abdel-Raouf Khallil

Publisher
John Wiley and Sons
Year
2003
Weight
117 KB
Volume
34
Category
Article
ISSN
0931-7597

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The deacylated chloramphenicol amine D-(-)-threo-2-amino-1-(4-nitrophenyl)-1,3-diol (D-amine, 1a), and its enantiomer, the L-(+)-threo-form (L-amine, 1b), were introduced into a tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) skeleton. They are incorporated in three ways (Chart 1, types I-III) at N3