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New Tetrahydro-2H-1,3,5-thiadiazine-2-thione Derivatives as Potential Antimicrobial Agents

✍ Scribed by Abdel-Nasser El-Shorbagi

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 67 KB
Volume: 333
Category: Article
ISSN: 0365-6233
DOI: 10.1002/1521-4184(20009)333:9<281::aid-ardp281>3.0.co;2-e

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✦ Synopsis

The deacylated chloramphenicol amine D-(-)-threo-2-amino-1-(4-nitrophenyl)-1,3-diol (D-amine, 1a), and its enantiomer, the L-(+)-threo-form (L-amine, 1b), were introduced into a tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) skeleton. They are incorporated in three ways (Chart 1, types I-III) at N3 (type I), N5 (type II) or both N3 and N5 (type III) of the THTT system. These selections were made in order to investigate the effect of combining the structural features of the THTT and the D-amine on the antimicrobial activity, if any.

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