The deacylated chloramphenicol amine D-(-)-threo-2-amino-1-(4-nitrophenyl)-1,3-diol (D-amine, 1a), and its enantiomer, the L-(+)-threo-form (L-amine, 1b), were introduced into a tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) skeleton. They are incorporated in three ways (Chart 1, types I-III) at N3
New 2H-Tetrahydro-1, 3, 5-thiadiazine-2-thiones Incorporating Glycine and Glycinamide as Potential Antifungal Agents
β Scribed by Tarek Aboul-Fadl; Mostafa A. Hussein; Abdel-Nasser El-Shorbagi; Abdel-Raouf Khallil
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 127 KB
- Volume
- 335
- Category
- Article
- ISSN
- 0365-6233
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Compounds having a-[dihydro-5-substitted 6-thioxo-2H-1.3.5-thiadiazine-3(4H)-yl]benzylpenicillin structure were synthesized by the reaction of ampicilliin trihydrate, formaldehyde and dithiocarbamic acid salts. The smctures were evident from chemical and spectral analysis. The antimicrobial activiti
A series of 4-(alkylidene/arylidene)amino-5-(2-furanyl)-2.4-dihydro-3H-I .2.4-triazolc-3-1hiones (2) and 6-aryl-3-(2-furanyl)-7H-12.4-triazolo[3,4-b]( 1.3.41 thiadiazines (3) werc synthesized. The configuration of 2g was assigned on che basis of 'H-NMR data. Of the new derivatives tesced. only 2b. 2