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Synthesis of 3-Substituted-5- (4-carboxycyclohexylmethyl)-tetrahydro-2H-1,3,5-thiadiazine-2-thione Derivatives as Antifibrinolytic and Antimicrobial Agents.

✍ Scribed by Azime Berna Oezcelik; Seyhan Ersan; Ali Ugur Ural; Semiha Oezkan; Mevluet Ertan


Publisher
John Wiley and Sons
Year
2007
Weight
15 KB
Volume
38
Category
Article
ISSN
0931-7597

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The deacylated chloramphenicol amine D-(-)-threo-2-amino-1-(4-nitrophenyl)-1,3-diol (D-amine, 1a), and its enantiomer, the L-(+)-threo-form (L-amine, 1b), were introduced into a tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) skeleton. They are incorporated in three ways (Chart 1, types I-III) at N3

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Compounds having a-[dihydro-5-substitted 6-thioxo-2H-1.3.5-thiadiazine-3(4H)-yl]benzylpenicillin structure were synthesized by the reaction of ampicilliin trihydrate, formaldehyde and dithiocarbamic acid salts. The smctures were evident from chemical and spectral analysis. The antimicrobial activiti