Neuroblastoma consensus deletion maps to 1p36.1–2

✍ Scribed by Dr. Andreas Weith; Tommy Martinsson; Celina Cziepluch; Silke Brüderlein; Lukas C. Amler; Frank Berthold; Manfred Schwab

• Book ID: 102844469
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 724 KB
• Volume: 1
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870010209

✦ Synopsis

At least 70% of human neuroblastomas display cytogenetically visible aberrations in the short arm of chromosome I . We have used a panel of probes detecting polymorphic D N A loci, most of which were derived from a library of microdissected distal I p chromosome fragments, to compare the hybridization pattern of D N A on nine different tumors and the corresponding normal tissue. In eight of the neuroblastomas allelic loss was observed with at least two probes. The deletions were of different size. Since a consensus deletion in all eight tumors included the segment lp36.1-2, we conclude that genetic information related to neuroblastoma tumorigenesis is located within this approximately I 0 megabase segment. Previous studies have revealed the amplification of MYCN in neuroblastomas. Our study did not provide evidence for a correlation between MYCN amplification and the I p deletion, suggesting that the two genetic alterations result from molecular mechanisms that are not directly related to each other.