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Identification and characterization of a 500-kb homozygously deleted region at 1p36.2-p36.3 in a neuroblastoma cell line

โœ Scribed by Ohira, Miki; Kageyama, Hajime; Mihara, Motohiro; Furuta, Shigeyuki; Machida, Taiichi; Shishikura, Tomotane; Takayasu, Hajime; Islam, Ashraful; Nakamura, Yohko; Takahashi, Masato

Book ID
110064102
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
303 KB
Volume
19
Category
Article
ISSN
0950-9232

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Identification of the homozygously delet
Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma
โœ Nakagawara, Akira ;Ohira, Miki ;Kageyama, Hajime ;Mihara, Motohiro ;Furuta, Shig ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 333 KB ๐Ÿ‘ 1 views

## Background: We have identified for the first time a homozygously deleted region within the smallest region of overlap at 1p36.2-3 in two neuroblastoma cell lines. ## Procedure: The 800-kb pac contig covering the entire homozygously deleted region was made and sequenced. to date, approximately

Homozygous deletion in a neuroblastoma c
Homozygous deletion in a neuroblastoma cell line defined by a high-density STS map spanning human chromosome band 1p36
โœ Ying Zhang Chen; Eiichi Soeda; Hong Wei Yang; Junko Takita; Ling Chai; Akira Hor ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 129 KB

## Abstract Recent molecular studies have shown a relatively high rate of loss of heterozygosity (LOH) in neuroblastoma (NB) as well as other types of tumors in human chromosome band 1p36. To identify candidate tumor suppressor genes in NB, we searched for homozygous deletions in NB cell lines with