Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma
โ Scribed by White, Peter S; Thompson, Patricia M; Gotoh, Takahiro; Okawa, Erin R; Igarashi, Jun; Kok, Marleen; Winter, Cynthia; Gregory, Simon G; Hogarty, Michael D; Maris, John M
- Book ID
- 110069368
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 332 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0950-9232
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## Background: We have identified for the first time a homozygously deleted region within the smallest region of overlap at 1p36.2-3 in two neuroblastoma cell lines. ## Procedure: The 800-kb pac contig covering the entire homozygously deleted region was made and sequenced. to date, approximately
## Abstract In human neuroblastomas, the distal portion of 1p is frequently deleted, as if one or more tumor suppressor genes from this region were involved in neuroblastoma tumorigenesis. Earlier studies had identified a smallest region of overlapping deletion (SRO) spanning approximately 23 cM be