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Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma

โœ Scribed by White, Peter S; Thompson, Patricia M; Gotoh, Takahiro; Okawa, Erin R; Igarashi, Jun; Kok, Marleen; Winter, Cynthia; Gregory, Simon G; Hogarty, Michael D; Maris, John M


Book ID
110069368
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
332 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Background: We have identified for the first time a homozygously deleted region within the smallest region of overlap at 1p36.2-3 in two neuroblastoma cell lines. ## Procedure: The 800-kb pac contig covering the entire homozygously deleted region was made and sequenced. to date, approximately

Smallest region of overlapping deletion
โœ Anja Bauer; Larissa Savelyeva; Andreas Claas; Christian Praml; Frank Berthold; M ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 339 KB

## Abstract In human neuroblastomas, the distal portion of 1p is frequently deleted, as if one or more tumor suppressor genes from this region were involved in neuroblastoma tumorigenesis. Earlier studies had identified a smallest region of overlapping deletion (SRO) spanning approximately 23 cM be