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Identification of the homozygously deleted region at chromosome 1p36.2 in human neuroblastoma

✍ Scribed by Nakagawara, Akira ;Ohira, Miki ;Kageyama, Hajime ;Mihara, Motohiro ;Furuta, Shigeyuki ;Machida, Taiichi ;Takayasu, Hajime ;Islam, Ashraful ;Nakamura, Yohko ;Takahashi, Masato ;Shishikura, Tomotane ;Kaneko, Yasuhiko ;Toyoda, Atsushi ;Hattori, Masahira ;Sakaki, Yoshiyuki ;Ohki, Misao ;Horii, Akira ;Soeda, Eiichi ;Inazawa, Johji ;Seki, Naohiko ;Kuma, Hidekazu ;Nozawa, Iwao ;Sakiyama, Shigeru

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 333 KB
Volume: 35
Category: Article
ISSN: 0098-1532
DOI: 10.1002/1096-911x(20001201)35:6<516::aid-mpo3>3.0.co;2-z

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✦ Synopsis

Background:

We have identified for the first time a homozygously deleted region within the smallest region of overlap at 1p36.2-3 in two neuroblastoma cell lines.

Procedure:

The 800-kb pac contig covering the entire homozygously deleted region was made and sequenced. to date, approximately 70% of sequencing has been accomplished, and the estimated length of the deleted region was 500 kb.

Results:

Currently, we have found six genes within the region, which include three known genes as well as three other genes that have been reported during processing of our present project for the last 3(1/2) years. we report here the results of expression and mutation analyses of those genes.

Conclusions:

Full sequencing for the region of homozygous deletion as well as further analyses of the genes mapped within the region may reveal whether or not there is a neuroblastoma suppressor gene as proposed by the knudson's two-hit hypothesis.

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