✦ LIBER ✦

Nephrotoxicity of ifosfamide in rats

✍ Scribed by James E. Springate; Judith B. van Liew

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 405 KB
Volume: 15
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550150510

No coin nor oath required. For personal study only.

✦ Synopsis

Renal proximal tubule cell injury is an important side effect of the chemotherapeutic agent ifosfamide in humans. We investigated the effect of this medication on kidney function in rats. Animals received either 40 or 80 mg kg-' ifosfamide intraperitoneally daily for 3 days every 3 weeks for a total of four treatment courses. Ifosfamide-treated rats had significantly lower body weight and hematocrit than sterile water-treated control rats. Animals receiving 40 mg kg-' ifosfarnide developed isolated phosphaturia after their fourth and final treatment course. Rats receiving 80 mg kg-' ifosfamide had low-grade glucosuria, phosphaturia and proteinuria throughout the study. Urine flow rate, creatinine clearance, urinary sodium and potassium excretion and kidney glutathione and malondialdehyde content were not affected by ifosfamide at either dose. These findings indicate that ifosfamide produces abnormalities in rat renal function resembling subclinical Fanconi syndrome.

📜 SIMILAR VOLUMES

Late reversibility of chronic ifosfamide

Late reversibility of chronic ifosfamide-associated nephrotoxicity in a child

✍ Ashraf, M. Shamvil; Skinner, Roderick; English, Martin W.; Craft, Alan W.; Pears 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 60 KB

Although reversibility of acute ifosfamide-in-famide) for prostatic rhabdomyosarcoma. Furduced nephrotoxicity is well documented, there ther investigation confirmed glomerular and is a paucity of data concerning the long-term generalised tubular dysfunction with a Fanconi outcome of chronic renal to

Development of ifosfamide-induced nephro

Development of ifosfamide-induced nephrotoxicity: prospective follow-up in 75 patients

✍ Rossi, Rainer; Pleyer, Julia; Sch�fers, Petra; Kuhn, Nanna; Kleta, Robert; Deufe 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB

## Purpose: This study was performed to describe prospectively the development and prognosis of severe ifosfamide-induced nephrotoxicity and to define the period of recommended renal follow-up after ifosfamide chemotherapy. ## Patients and methods: Renal function was followed in 75 patients after

Transient and reversible nephrotoxicity

Transient and reversible nephrotoxicity of sarin in rats

✍ Eugenia Bloch-Shilderman; Aharon Levy 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB 👁 1 views

## Abstract Organophosphate (OP) poisoning, which inhibits cholinesterase activity, leads to severe cholinergic symptoms. Effective and quick management of these symptoms is considered critical to the clinical outcome. Acute renal damage following exposure to OP insecticides has been reported. Simi

Spirulina attenuates cyclosporine-induce

Spirulina attenuates cyclosporine-induced nephrotoxicity in rats

✍ Mahmood Khan; Jagdish Chandra Shobha; Iyyapu Krishna Mohan; Madireddy Umamaheswa 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB

## Abstract Cyclosporine (CsA) causes a dose‐related decrease in renal function in experimental animals and humans. The generation of reactive oxygen species (ROS) has been implicated in CsA‐induced nephrotoxicity. It was previously shown that __Spirulina__, a blue‐green algae, with antioxidant pro

Nephrotoxic Effects of Unleaded Petrol i

Nephrotoxic Effects of Unleaded Petrol in Female Rats

✍ A. Vyskocil; M. Cizkova 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 168 KB 👁 2 views

Female Wistar rats were exposed to 4 g m-3 unleaded petrol for 8 h a day, 5 days a week for 60 days. Urinary P,-microglobulin ( Pz-m), lactate dehydrogenase (LDH) and lysozyme were used as markers of tubular dysfunction. Urinary excretion of albumin and the glomerular filtration rate (GFR) were used

Beneficial effect of acetylcysteine on c

Beneficial effect of acetylcysteine on cisplatin nephrotoxicity in rats

✍ Dorothea Appenroth; Klaus Winnefeld; Heinz Schröter; Michael Rost 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB 👁 2 views

## Abstract The influence of acetylcysteine (ac‐cys) on cisplatin (CP) nephrotoxicity was investigated in female Wistar rats. Administration of 0.6 mg CP 100 g^−1^ body wt. was followed by oliguria and proteinuria, as well as a significant increase of blood urea nitrogen concentration. The i.p. adm