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Negative regulation of EphA2 receptor by Cbl

✍ Scribed by You-jie Wang; Satoshi Ota; Hideki Kataoka; Masao Kanamori; Zhong-you Li; Hamid Band; Masamitsu Tanaka; Haruhiko Sugimura

Book ID
117052277
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
334 KB
Volume
296
Category
Article
ISSN
0006-291X

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## Abstract Estrogen receptor and c‐Myc are frequently overexpressed during breast cancer progression but are downregulated in many aggressive forms of the disease. High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression c