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Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase

✍ Scribed by Shao, Yuan; Elly, Chris; Liu, Yun-Cai

Book ID
110033591
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
320 KB
Volume
4
Category
Article
ISSN
1469-221X

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## Abstract **Background:** Recent studies have demonstrated that c‐Cbl functions as a ubiquitin‐protein ligase toward immune receptors and non‐receptor protein‐tyrosine kinase Syk by facilitating their ubiquitination and subsequent targeting to proteasomes. However, it was not clear whether Src fa