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Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

✍ Scribed by Daniel P. Zelinski; Nicole Dodge Zantek; Jennifer Walker-Daniels; Mette A. Peters; Elizabeth J. Taparowsky; Michael S. Kinch

Book ID
102299662
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
193 KB
Volume
85
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Estrogen receptor and c‐Myc are frequently overexpressed during breast cancer progression but are downregulated in many aggressive forms of the disease. High levels of the EphA2 tyrosine kinase are consistently found in the most aggressive breast cancer cells, and EphA2 overexpression can increase metastatic potential. We demonstrate, herein, that estrogen and Myc negatively regulate EphA2 expression in mammary epithelial cells. These data reveal EphA2 as a downstream target of estrogen and Myc and suggest a mechanism by which estrogen and Myc may regulate breast cancer. J. Cell. Biochem. 85: 714–720, 2002. Β© 2002 Wiley‐Liss, Inc.

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