Nucleic acid structures are highly conserved through evolution and when self nucleic acids are aberrantly detected by toll-like receptors (TLRs) they contribute to autoimmune disease. For this reason, multiple regulatory mechanisms exist to prevent immune responses to self nucleic acids. TLR9 is a n
The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction
β Scribed by Mark L Lupher Jr; Navin Rao; Michael J Eck; Hamid Band
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 348 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
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## Abstract A healthy intestinal tract is characterized by controlled homeostasis due to the balanced interaction between commensal bacteria and the host mucosal immune system. Human and animal model studies have supported the hypothesis that breakdown of this homeostasis may underlie the pathogene