Neck weakness is a potent prognostic factor in sporadic amyotrophic lateral sclerosis patients
β Scribed by Nakamura, R.; Atsuta, N.; Watanabe, H.; Hirakawa, A.; Watanabe, H.; Ito, M.; Senda, J.; Katsuno, M.; Tanaka, F.; Izumi, Y.; Morita, M.; Ogaki, K.; Taniguchi, A.; Aiba, I.; Mizoguchi, K.; Okamoto, K.; Hasegawa, K.; Aoki, M.; Kawata, A.; Abe, K.; Oda, M.; Konagaya, M.; Imai, T.; Nakagawa, M.; Tsuji, S.; Kaji, R.; Nakano, I.; Sobue, G.; Yuasa, T.; Kano, T.; Sasaki, H.; Kato, M.; Ishihara, T.; Nishizawa, M.; Ikeda, M.; Shibuya, K.; Kuwabara, S.; Hayashi, H.; Takahashi, Y.; Tomiyama, H.; Hattori, N.; Aizawa, H.; Kano, O.; Iwasaki, Y.; Nagasaka, T.; Takiyama, Y.; Sakai, M.; Shiga, K.; Yamashita, H.; Takahashi, R.; Fujita, T.; Yamashita, T.; Hiji, M.; Watanabe, Y.; Nakashima, K.; Hayashi, S.; Kira, J.-i.
- Book ID
- 123613421
- Publisher
- BMJ Publishing Group
- Year
- 2013
- Tongue
- English
- Weight
- 829 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0022-3050
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The pathogenesis of idiopathic amyotrophic lateral sclerosis (ALS) remains unknown, but accumulating evidence suggests a neuroexcitotoxic mechanism may have some credence. Glutamate-induced hyperexcitability of cortical or spinal motoneurons may be expected to manifest itself as a reduced threshold
## Abstract ## Objective To elucidate the role of cyclooxygenaseβ1 (Cox1) and prostaglandin E~2~ in ALS neurodegeneration. ## Methods Mutation in superoxide dismutaseβ1 is a cause of the fatal paralytic disorder amyotrophic lateral sclerosis. Inhibition of cyclooxygenaseβ2 (Coxβ2) in transgenic