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ZNF512B gene is a prognostic factor in patients with amyotrophic lateral sclerosis

✍ Scribed by Syuichi Tetsuka; Mitsuya Morita; Aritoshi Iida; Ritei Uehara; Shiro Ikegawa; Imaharu Nakano

Book ID
119304715
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
302 KB
Volume
324
Category
Article
ISSN
0022-510X

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## Abstract ## Objective To elucidate the role of cyclooxygenase‐1 (Cox1) and prostaglandin E~2~ in ALS neurodegeneration. ## Methods Mutation in superoxide dismutase‐1 is a cause of the fatal paralytic disorder amyotrophic lateral sclerosis. Inhibition of cyclooxygenase‐2 (Cox‐2) in transgenic