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Is erythropoietin gene a modifier factor in amyotrophic lateral sclerosis?

✍ Scribed by Serena Ghezzi; Roberto Del Bo; Marina Scarlato; Martina Nardini; Cecilia Carlesi; Alessandro Prelle; Stefania Corti; Michelangelo Mancuso; Chiara Briani; Gabriele Siciliano; Luigi Murri; Nereo Bresolin; Giacomo Pietro Comi

Book ID
116781199
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
74 KB
Volume
30
Category
Article
ISSN
0197-4580

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Is prostaglandin E2 a pathogenic factor
Is prostaglandin E2 a pathogenic factor in amyotrophic lateral sclerosis?
✍ Gabriele Almer; Hitoshi Kikuchi; Peter Teismann; Serge Przedborski πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 158 KB

## Abstract ## Objective To elucidate the role of cyclooxygenase‐1 (Cox1) and prostaglandin E~2~ in ALS neurodegeneration. ## Methods Mutation in superoxide dismutase‐1 is a cause of the fatal paralytic disorder amyotrophic lateral sclerosis. Inhibition of cyclooxygenase‐2 (Cox‐2) in transgenic