Transfer factor is ineffective in amyotrophic lateral sclerosis
β Scribed by Dr. Marcelo R. Olarte; Joanne C. Gersten; John Zabriskie; Lewis P. Rowland
- Publisher
- John Wiley and Sons
- Year
- 1979
- Tongue
- English
- Weight
- 312 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Objective To elucidate the role of cyclooxygenaseβ1 (Cox1) and prostaglandin E~2~ in ALS neurodegeneration. ## Methods Mutation in superoxide dismutaseβ1 is a cause of the fatal paralytic disorder amyotrophic lateral sclerosis. Inhibition of cyclooxygenaseβ2 (Coxβ2) in transgenic
The pathogenesis of idiopathic amyotrophic lateral sclerosis (ALS) remains unknown, but accumulating evidence suggests a neuroexcitotoxic mechanism may have some credence. Glutamate-induced hyperexcitability of cortical or spinal motoneurons may be expected to manifest itself as a reduced threshold