Nad(p)+-nad(p)H model. Reduction of pyridinium salts to 1,4-dihydropyridines using glyceraldehyde
✍ Scribed by Atsuyoshi Ohno; Satoshi Ushida; Shinzaburo Oka
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 217 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
N-Substituted 3-carbamoylpyridinium salts were reduced by glyceraldehyde to give 1,4-dihydronicotinamide derivatives, which may be regarded as a model for oxidation by glyceraldehyde-3-phosphate dehydrogenase.
📜 SIMILAR VOLUMES
## Abstract Pyrrolidinium salts derived from a series of 17‐substituted Δ^4^‐3‐ketosteroids are reduced by 1‐benzyl‐1,4‐dihydronicotinamide (BNAH) and 2,6‐dimethyl‐3,5‐diethoxycarbonyl‐1,4‐dihydropyridine (Hantzsch ester, 1 eq.) to the corresponding isomeric 5α‐ and 5β‐enamines which hydrolyse to t
In spite of tremendous works on mimetic reactions of NAD(P)H-dependent dehydrogenases, 1 stereochemical problem has not been paid much attention. Recently, we reported that optically active 1,4-dihydronicotinamide derivatives, in which the chiral center is separated from the reaction center by five