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Nad(p)+-nad(p)H model. Reduction of pyridinium salts to 1,4-dihydropyridines using glyceraldehyde

✍ Scribed by Atsuyoshi Ohno; Satoshi Ushida; Shinzaburo Oka


Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
217 KB
Volume
23
Category
Article
ISSN
0040-4039

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✦ Synopsis


N-Substituted 3-carbamoylpyridinium salts were reduced by glyceraldehyde to give 1,4-dihydronicotinamide derivatives, which may be regarded as a model for oxidation by glyceraldehyde-3-phosphate dehydrogenase.


📜 SIMILAR VOLUMES


NAD(P)H models XV. Reduction of Δ4-3-ket
✍ Ronald A. Case; Upendra K. Pandit 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 607 KB

## Abstract Pyrrolidinium salts derived from a series of 17‐substituted Δ^4^‐3‐ketosteroids are reduced by 1‐benzyl‐1,4‐dihydronicotinamide (BNAH) and 2,6‐dimethyl‐3,5‐diethoxycarbonyl‐1,4‐dihydropyridine (Hantzsch ester, 1 eq.) to the corresponding isomeric 5α‐ and 5β‐enamines which hydrolyse to t

Reduction by a model of NAD(P)H. Contrib
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In spite of tremendous works on mimetic reactions of NAD(P)H-dependent dehydrogenases, 1 stereochemical problem has not been paid much attention. Recently, we reported that optically active 1,4-dihydronicotinamide derivatives, in which the chiral center is separated from the reaction center by five