NAD(P)+-NAD(P)H model. 38. Reduction of aldehyde by 1,4-dihydroquinolin derivative
✍ Scribed by Atsuyoshi Ohno; Yuji Ishihara; Satoshi Ushida; Shinzaburo Oka
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 196 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
N-Substituted 3-carbamoylpyridinium salts were reduced by glyceraldehyde to give 1,4-dihydronicotinamide derivatives, which may be regarded as a model for oxidation by glyceraldehyde-3-phosphate dehydrogenase.
With respect to enzymatic reductions of carbonyl compounds by reduced pyridine nucleotides,NAD(P)H,wedescribedpreviouslychemicalreduction, assisted by a divalent metal ion such as Mg++ or Zn ++,of a-keto esters with 1-benzyl-1,4dihydronicotinamide(BNAH) as a model of NAD(P)H'! This mimicry has beene
## Abstract Pyrrolidinium salts derived from a series of 17‐substituted Δ^4^‐3‐ketosteroids are reduced by 1‐benzyl‐1,4‐dihydronicotinamide (BNAH) and 2,6‐dimethyl‐3,5‐diethoxycarbonyl‐1,4‐dihydropyridine (Hantzsch ester, 1 eq.) to the corresponding isomeric 5α‐ and 5β‐enamines which hydrolyse to t