Reduction by a model of NAD(P)H. XXVI. reduction of C=C bond in 1,3,5-trinitrobenzene
✍ Scribed by Atsuyoshi Ohno; Hiroyuki Yamamoto; Shinzaburo Oka
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 199 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
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In spite of tremendous works on mimetic reactions of NAD(P)H-dependent dehydrogenases, 1 stereochemical problem has not been paid much attention. Recently, we reported that optically active 1,4-dihydronicotinamide derivatives, in which the chiral center is separated from the reaction center by five
## Abstract Pyrrolidinium salts derived from a series of 17‐substituted Δ^4^‐3‐ketosteroids are reduced by 1‐benzyl‐1,4‐dihydronicotinamide (BNAH) and 2,6‐dimethyl‐3,5‐diethoxycarbonyl‐1,4‐dihydropyridine (Hantzsch ester, 1 eq.) to the corresponding isomeric 5α‐ and 5β‐enamines which hydrolyse to t