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Reduction by a model of NAD(P)H. Contribution of metal ion to asymmetric reduction of trifluoroacetophenone

✍ Scribed by Yutaka Ohnishi; Takashi Numakunai; Atsuyoshi Ohno

Publisher: Elsevier Science
Year: 1975
Tongue: French
Weight: 124 KB
Volume: 16
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)91281-4

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✦ Synopsis

In spite of tremendous works on mimetic reactions of NAD(P)H-dependent dehydrogenases, 1 stereochemical problem has not been paid much attention.

Recently, we reported that optically active 1,4-dihydronicotinamide derivatives, in which the chiral center is separated from the reaction center by five atoms, results in asymmetric reduction of a-keto esters by the aid of magnesium or zinc perchlorate.

2 We wish now to present the stereochemical results from the reaction of a,a,a-trifluoroacetophenone

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